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Blue Horizon DNA

Blue Horizon Thyroid Genetic Panel

We are pleased to let you know that Blue Horizon now have a thyroid genetic panel which checks for various thyroid polymorphisms.

Special January 2018 Offer!
The cost of this panel is usually £199.15 but if you use the code TUKDNAJAN it will give £60 off in the month of January meaning that you will pay just £139.15 for the entire profile.
You will also be supporting us as Blue Horizon will be donating £5 for each test purchased.

Gene and SNP inclusions

DIO1 - Thyroid Hormone Activation
“D1” is largely expressed in the liver and kidneys. It is responsible for the clearance of rT3 from circulation, and for facilitating the conversion of T4 to T3 in plasma and surrounding tissue. This process requires selenium and iodine for optimum function. Here we look at two variants linked to poor conversion of T4 to T3 and
reduced clearance of RT3.

DIO2 - Thyroid Hormone Activation
“D2” is importantly expressed in the central nervous system, pituitary, brown fat tissue and muscle, and responds to changes in thyroid levels. D2 is responsible for the ‘local’ conversion of T4 to T3 in the thyroid, placenta and brain. It requires selenium and iodine to function optimally. Here we look at two different variants linked to decreased T4 and low mood in certain individuals.

COMT - Inactivation of Stress Hormones and Oestrogen
COMT is one of the main inactivating enzymes of stress hormones and oestrogen in the body. COMT variants cause slow clearance of stress hormones and oestrogen leading to high oestrogen and stress hormone levels which may also be linked to thyroid hormone dysfunction.

FKBP5 - Cortisol Regulation
FKBP5 is an important stress-regulating gene responsible for lowering cortisol levels after a stress response. Variants are associated with prolonged and increased symptoms of stress, which may be due to delayed lowering of cortisol levels.

PDE8B - TSH Signalling
PDE8B is found in the thyroid but not the pituitary, and is involved in TSH signalling. It is thought that the variant decreases the response of the thyroid gland to TSH stimulation

TNF-a - Inflammation
TNF-a is an inflammatory cytokine that helps regulate the immune reaction involved in inflammation, giving rise to fever and inhibiting tumour growth. If poorly controlled, it may be implicated in a number of autoimmune disorders. Variants in TNFa are associated with overreactive immune responses and prolonged inflammation.

TSHR - Thyroid Stimulating Hormone (TSH) Receptor
The TSHR gene plays a central role in thyroid metabolism by controlling the thyroid gland’s receptivity to TSH. Variants in this gene have been linked to hyperthyroidism, particularly to Graves’ Disease (GD).

TRHR - Thyrotropin Releasing Hormone (TRH) Receptor
Responsible for the body’s receptivity to TRH which stimulates the secretion of TSH from the pituitary gland. In turn, TSH stimulates the production of thyroid hormones from the thyroid gland. TRH is an important part of the negative feedback loop that ultimately regulates thyroid hormone levels. Variants have been shown to affect TSH levels.

Your results include information on your thyroid genotype and gives advice which is very useful.

For more information on this test go to:

For a sample test result report go to:

The cost of this panel is usually £199.15
Blue Horizon will be donating £5 to Thyroid UK for each test purchased.

Blue Horizon Medicals Ltd., Tavyside Clinic, Whitchurch Road, Tavistock PL19 9BB
Telephone: 0800 0988 751 Fax number: 0844 357 6601
E-mail address: assistance@bluehorizonmedicals.co.uk
Website: http://www.bluehorizonmedicals.co.uk